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Microbial transformation of pseudoprotodioscin by Gibberella fujikuroi.
- Source :
-
Journal of Asian Natural Products Research . Jul2018, Vol. 20 Issue 7, p624-632. 9p. - Publication Year :
- 2018
-
Abstract
- Three new (6, 9, and 12) and nine known steroidal saponins were obtained from the fermentation broth of pseudoprotodioscin (PPD) incubated with a fungus Gibberella fujikuroi CGMCC 3.4663. Structures of the metabolites were elucidated by 1-D (1H, 13C), 2-D (HMBC, HSQC, NOESY) NMR, and HR-MS analyses. The biotransformation pathway of pseudoprotodioscin by Gibberella fujikuroi CGMCC 3.4663 was proposed. Compounds 1-11 were tested in vitro for their cytotoxic activities against two human cancer cell lines (HepG2 and Hela). Compounds 1, 6, 9, and 10 exhibited cytotoxic activity against HepG2 cells. Compound 10 exhibited cytotoxicity to Hela cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FUNGAL metabolism
*BIOTRANSFORMATION (Metabolism)
*CELL lines
*CULTURE media (Biology)
*FERMENTATION
*GLYCOSIDES
*HERBAL medicine
*HIGH performance liquid chromatography
*HYDROXYLATION
*MASS spectrometry
*CHINESE medicine
*METABOLISM
*MOLECULAR structure
*NUCLEAR magnetic resonance spectroscopy
*OXIDATION-reduction reaction
*PROTON magnetic resonance spectroscopy
*RESEARCH funding
*IN vitro studies
*STEROIDAL anti-inflammatory agents
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 20
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 133104345
- Full Text :
- https://doi.org/10.1080/10286020.2018.1468438