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TET2 rs2454206, TET2 rs12498609 and ASXL1 rs3746609 single nucleotide polymorphisms in patients with myelodysplastic syndromes.
- Source :
-
Blood Cells, Molecules & Diseases . Feb2019, Vol. 74, p44-50. 7p. - Publication Year :
- 2019
-
Abstract
- Abstract To study the association between TET2 rs2454206, TET2 rs12498609 and ASXL1 rs3746609 and Myelodysplastic syndromes (MDS), a total of 90 MDS patients and 143 healthy volunteers were included. The clinical data, bone marrow samples of patients and peripheral blood samples of volunteers were obtained. We found TET2 rs2454206 G/A genotype, TET2 rs12498609 G/C genotype and ASXL1 rs3746609 A/G genotype in 13.3%, 11.1%, 10.1% MDS patients and in 42.7%, 22.4%, 23.8% healthy volunteers (P < 0.001; P = 0.029; P = 0.009, respectively). TET2 rs2454206 G/A genotype was associated with higher serum LDH level in MDS (P = 0.025). Patients with TET2 rs12498609 G/C genotype were characterized with higher frequency of mutated SRSF2 gene (P = 0.042) and lower occurrence rate of anemia (P = 0.026) than those with C/C genotype. ASXL1 rs3746609 A/G genotype linked with higher thrombocyte counts (P = 0.02) and percent of total T lymphocyte (P = 0.029), whereas with lower percent of NK cell (P = 0.032) and B lymphocyte (P = 0.007). None of these three SNPs had impact on the overall survival and disease progression to AML. We concluded that People with TET rs2454206 G/A genotype, TET2 rs12498609 G/C genotype or ASXL1 rs3746609 A/G genotype were related to lower prevalence of MDS. All of the three SNPs were associated with certain laboratory features in MDS patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10799796
- Volume :
- 74
- Database :
- Academic Search Index
- Journal :
- Blood Cells, Molecules & Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 133068242
- Full Text :
- https://doi.org/10.1016/j.bcmd.2018.11.002