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European paediatric non-alcoholic fatty liver disease registry (EU-PNAFLD): Design and rationale.
- Source :
-
Contemporary Clinical Trials . Dec2018, Vol. 75, p67-71. 5p. - Publication Year :
- 2018
-
Abstract
- Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in children and has the potential to progress to advanced fibrosis/cirrhosis, end-stage liver disease and hepatocellular carcinoma. However, the natural history of the condition is poorly understood and there are no approved treatments. The European Paediatric Non-Alcoholic Fatty Liver Disease Registry (EU-PNAFLD) is a multi-centre registry of paediatric NAFLD that will serve as a prospective, observational, natural history study and provide a tractable back-bone to support recruitment into subsequent interventional trials. Collection of samples into a bio-repository will facilitate translational studies, including genome sequencing and metabolomics. EU-PNAFLD will work closely alongside the existing adult European NAFLD Registry to obtain data on clinical outcomes after 20–30 years. Through an international, well-characterised large-scale cohort, EU-PNAFLD will address the key questions in paediatric NAFLD and benefit patients with the condition. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FATTY liver
*LIVER cancer
*JUVENILE diseases
*NUCLEOTIDE sequencing
*METABOLOMICS
Subjects
Details
- Language :
- English
- ISSN :
- 15517144
- Volume :
- 75
- Database :
- Academic Search Index
- Journal :
- Contemporary Clinical Trials
- Publication Type :
- Academic Journal
- Accession number :
- 133067438
- Full Text :
- https://doi.org/10.1016/j.cct.2018.11.003