NaN3/NH4Cl‐Promoted Aza‐Cyclization: A Convenient Route for Bio‐Active Diverse Isoindolinone Derivatives.

An efficient substrate dependent NaN3/NH4Cl promoted aza‐cyclization was developed via metal free cascade transformation. A wide variety of bicyclic/tricyclic isoindolinone derivative was achieved with excellent diastereoselectivity from achiral reagent system. This protocol also provided synthetic route of dopamine D4 receptor in short way. The bio‐imaging study towards CHO cell line with our isoindolinone embedded new fluorophore was also demonstrated. An efficient substrate dependent NaN3/NH4Cl promoted aza‐cyclization was developed via metal free cascade transformation. A wide variety of bicyclic/tricyclic isoindolinone derivative was achieved with excellent diastereoselectivity from achiral reagent system. This protocol also provided synthetic route of dopamine D4 receptor in short way. The bio‐imaging study towards CHO cell line with our isoindolinone embedded new fluorophore was also demonstrated. [ABSTRACT FROM AUTHOR]