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Feasibility of the string test for tuberculosis diagnosis in children between 4 and 14 years old.
- Source :
-
BMC Infectious Diseases . 11/15/2018, Vol. 18 Issue 1, p1-8. 8p. 4 Charts, 1 Graph. - Publication Year :
- 2018
-
Abstract
- <bold>Background: </bold>The enteric string test can be used to obtain a specimen for microbiological confirmation of tuberculosis in children, but it is not widely used for this. The aim of this analysis to evaluate this approach in children with tuberculosis symptoms.<bold>Methods: </bold>We conducted a cross-sectional study to assess children's ability to complete the test (feasibility), and self-reported pain (tolerability). We examined caregivers' and children's willingness to repeat the procedure (acceptability) and described the diagnostic yield of cultures for diagnostic tools. We stratified estimates by age and compared metrics to those derived for gastric aspirate (GA).<bold>Results: </bold>Among 148 children who attempted the string test, 34% successfully swallowed the capsule. Feasibility was higher among children aged 11-14 than in children 4-10 years (83% vs 22% respectively, p < 0.0001). The string test was better tolerated than GA in both age groups; however, guardians and older children reported higher rates of willingness to repeat GA than the string test (86% vs. 58% in children; 100% vs. 83% in guardians). In 9 children with a positive sputum culture, 6 had a positive string culture. The one children with a positive gastric aspirate culture also had a positive string culture.<bold>Conclusion: </bold>Although the string test was generally tolerable and accepted by children and caregivers; feasibility in young children was low. Reducing the capsule size may improve test success rates in younger children. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TUBERCULOSIS in children
*BACTERIAL diseases in children
*PEDIATRIC respiratory diseases
*FEASIBILITY studies
*PEDIATRIC pulmonology
*TUBERCULOSIS diagnosis
*TUBERCULOSIS microbiology
*COMPARATIVE studies
*GASTRIC juice
*RESEARCH methodology
*MEDICAL cooperation
*MYCOBACTERIUM tuberculosis
*RESEARCH
*PILOT projects
*EVALUATION research
*PAIN measurement
*PREDICTIVE tests
*CROSS-sectional method
*MEDICAL suction
*PATIENTS' attitudes
*ROUTINE diagnostic tests
Subjects
Details
- Language :
- English
- ISSN :
- 14712334
- Volume :
- 18
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- BMC Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 133042101
- Full Text :
- https://doi.org/10.1186/s12879-018-3483-0