Rosmarinus officinalis L. Sulu Ekstraktının İzole Edilmiş Rat Midesinde Mide Asit Salgısı Üzerine Etkisi.

In this study, the in vitro effect of Rosmarinus officinalis L. (Rosemary) aqueous extract on rat gastric acid secretion was investigated. 24 male Sprague Dawley male rats were used in the study. Rats were euthanized by cervical dislocation in the presence of ketamine hydrochloride (Ketalar: 75 mg / kg) and xylazine (Rompun: 15 mg / kg) anesthesia. The isolated stomachs were left in the isolated organ bath for 1 hour for the incubation period. At the end of this period, the pH of the mucosal fluid obtained from the stomachs was evaluated as the basal pH. Histamine was then applied to the bath environment to induce stomach acid secretion and the pH values of the stomach contents were measured. Four different doses of Rosemary extract (150, 300, 600 and 1200 µg / ml) were applied to the bath separately and the pH of the stomach contents was recorded. In addition, Rosemary Extract's four separate doses were applied to the individual baths with Histamine and the pH values of the stomach contents were determined. The resulting pH values were compared to the basal pH and the PH values were calculated. In conclusion, the effect of 150 µg / ml dose of Rosemary extract on gastric acid secretion was not statistically significant and doses of 300, 600 and 1200 µg / ml increased stomach acid secretion statistically significantly. [ABSTRACT FROM AUTHOR]