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Cyclooxygenase-2 expression in Schwann cells and macrophages in the sciatic nerve after single spinal nerve injury in rats
- Source :
-
Neuroscience Letters . Jun2004, Vol. 363 Issue 3, p203-206. 4p. - Publication Year :
- 2004
-
Abstract
- Recent evidence suggested that cyclooxygenase-2 (COX-2) expression in the peripheral nerve early after nerve injury might be involved in the development of neuropathic pain. Although previous investigators have demonstrated that COX-2 is expressed in peripheral nerve at a late phase (2–4 weeks) after nerve injury, COX-2 up-regulation at an early phase after nerve injury has not been determined. Using immunohistochemistry, we observed biphasic increases of COX-2 expression after L5 single spinal nerve injury. The first increment of COX-2 positive cells was noted 1 day after nerve injury and these cells co-expressed the Schwann cell marker S-100. A second increment was noted after 7–14 days and these cells co-expressed the macrophage marker ED-1. These results suggested that the cellular sources of COX-2 expression might be different between the early and late phases after nerve injury. [Copyright &y& Elsevier]
- Subjects :
- *CYCLOOXYGENASE 2
*MYELIN sheath
*SCIATIC nerve
*SPINAL nerves
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 363
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 13291730
- Full Text :
- https://doi.org/10.1016/j.neulet.2004.03.040