Parallel Asynchronous Differential Evolution Method for the SAXS/SANS Analysis of the PTNS-based Vesicles Structure.

The parallel Asynchronous Differential Evolution (ADE) method with adaptive correlation matrix (ACM) is utilized for numerical solution of the global minimization problem within the Separated Form Factors model (SFF) for analysis of structure of the drug-delivering phospholipid transport nanosystem (PTNS). In this framework, parameters of the SFF model are fitted to experimental data of the small angle scattering of X-rays (SAXS) and of neutrons (SANS). The ADE-SFF approach is described, the results of numerical study of polydispersed PTNS-based systems in water solutions depending on the disaccharide concentration, are presented. [ABSTRACT FROM AUTHOR]