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SIV/SHIV-Zika co-infection does not alter disease pathogenesis in adult non-pregnant rhesus macaque model.
- Source :
-
PLoS Neglected Tropical Diseases . 10/25/2018, Vol. 12 Issue 10, p1-12. 12p. - Publication Year :
- 2018
-
Abstract
- Due to the large geographical overlap of populations exposed to Zika virus (ZIKV) and human immunodeficiency virus (HIV), understanding the disease pathogenesis of co-infection is urgently needed. This warrants the development of an animal model for HIV-ZIKV co-infection. In this study, we used adult non-pregnant macaques that were chronically infected with simian immunodeficiency virus/chimeric simian human immunodeficiency virus (SIV/SHIV) and then inoculated with ZIKV. Plasma viral loads of both SIV/SHIV and ZIKV co-infected animals revealed no significant changes as compared to animals that were infected with ZIKV alone or as compared to SIV/SHIV infected animals prior to ZIKV inoculation. ZIKV tissue clearance of co-infected animals was similar to animals that were infected with ZIKV alone. Furthermore, in co-infected macaques, there was no statistically significant difference in plasma cytokines/chemokines levels as compared to prior to ZIKV inoculation. Collectively, these findings suggest that co-infection may not alter disease pathogenesis, thus warranting larger HIV-ZIKV epidemiological studies in order to validate these findings. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RH factor
*ZIKA virus
*ZIKA virus infections
*HIV
*HIV antibodies
Subjects
Details
- Language :
- English
- ISSN :
- 19352727
- Volume :
- 12
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- PLoS Neglected Tropical Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 132588002
- Full Text :
- https://doi.org/10.1371/journal.pntd.0006811