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An improved and efficient synthesis of panobinostat.
- Source :
-
Journal of Chemical Research . Sep2018, Vol. 42 Issue 9, p471-473. 3p. - Publication Year :
- 2018
-
Abstract
- An improved and efficient method for the synthesis of panobinostat was developed. The commercially available starting material 4-(chloromethyl)benzaldehyde was converted to (E)-methyl 3-[4-(chloromethyl)phenyl]acrylate via the Wittig--Horner reaction and was then directly condensed with 2-(2-methyl-1H-indol-3-yl)ethanamine to afford the key intermediate (E)-methyl3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]acrylate in a one-pot synthesis reactor. Subsequently a nucleophilic substitution reaction was carried out smoothly to generate the desired compound. The key intermediate and target compound were characterised by HRMS, ¹H NMR and 13C NMR. This procedure is operationally simple and would be more suitable for industrial production. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17475198
- Volume :
- 42
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Chemical Research
- Publication Type :
- Academic Journal
- Accession number :
- 132452326
- Full Text :
- https://doi.org/10.3184/174751918X15357309308931