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Stereoselective conjugate addition of ketones to alkylidene malonates using thiourea‐sulfonamide organocatalyst.
- Source :
-
Chirality . Nov2018, Vol. 30 Issue 11, p1215-1224. 10p. - Publication Year :
- 2018
-
Abstract
- In this study, stereoselective conjugate addition of ketones to alkylidene malonates using organocatalyst has been developed. The reaction in the presence of 20 mol% of a novel thiourea‐sulfonamide organocatalyst afforded conjugate adducts in moderate to high yields (up to 81%) under mild reaction conditions. Excellent diastereoselectivity (up to 98:2 dr) and enantioselectivity (up to 88% ee) were achieved. [ABSTRACT FROM AUTHOR]
- Subjects :
- *STEREOSELECTIVE reactions
*KETONES
*ALKYLIDENES
*MALONATES
*SULFONAMIDES
Subjects
Details
- Language :
- English
- ISSN :
- 08990042
- Volume :
- 30
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Chirality
- Publication Type :
- Academic Journal
- Accession number :
- 132424849
- Full Text :
- https://doi.org/10.1002/chir.23015