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Long non-coding RNA-mediated regulation of signaling pathways in gastric cancer.
- Source :
-
Clinical Chemistry & Laboratory Medicine . Nov2018, Vol. 56 Issue 11, p1828-1837. 10p. 1 Diagram, 3 Charts. - Publication Year :
- 2018
-
Abstract
- Gastric cancer (GC) is one of the most common cancers globally. Because of the high frequency of tumor recurrence, or metastasis, after surgical resection, the prognosis of patients with GC is poor. Therefore, exploring the mechanisms underlying GC is of great importance. Recently, accumulating evidence has begun to show that dysregulated long non-coding RNAs (lncRNAs) participate in the progression of GC via several typical signaling pathways, such as the AKT and MAPK signaling pathways. Moreover, the interactions between lncRNAs and microRNAs appear to represent a novel mechanism in the pathogenesis of GC. This review provides a synopsis of the latest research relating to lncRNAs and associated signaling pathways in GC. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14346621
- Volume :
- 56
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Clinical Chemistry & Laboratory Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 132421753
- Full Text :
- https://doi.org/10.1515/cclm-2017-1139