Akut yüzme egzersizi yaptırılan diyabetik sıçanlarda intraperitoneal çinko sülfat uygulamasının kas dokusundaki lipid peroksidasyonuna etkisi*.

Objective: The objective of the present study is to explore the effect of zinc supplementation on lipid peroxidation and antioxidant capacity in the muscle tissue of rats which were induced diabetes with streptozotocin and subjected to acute swimming exercise. Material and Method: The study included 80 adult, male, Spraque-Dawley type rats, which were equally allocated to 8 groups. Group 1, general control. Group 2, zinc-supplemented control. Group 3, zinc-supplemented diabetic control. Group 4, swimming control. Group 5, zinc-supplemented swimming. Group 6, zinc-supplemented diabetic swimming. Group 7, diabetic swimming. Group 8, diabetes group. The animals were injected with 40 mg/kg intraperitoneal (ip) streptozotocin (STZ) to induce diabetes. The injections were repeated after 24 hours. The animals whose blood glucose stood at or over 300 mg/dl on day 6 following the last injection were considered diabetic. The animals were supplemented with 6 mg/kg/day ip zinc sulfate for 4 weeks. At the end of the 4-week study, the animals were decapitated to collect muscle tissue samples, which were analyzed in terms of MDA (nmol/gram/protein) and GSH (mg/dl/gram protein) levels. Results: The highest MDA values in the muscle tissue were established in groups 4 and 7. Muscle MDA levels in groups 5 and 6 were lower than those in groups 4 and 7, but higher than the levels in all other groups. Groups 5 and 6 had the highest muscle GSH values. Group 4 had this parameter lower than groups 5 and 6, but higher than others. The lowest GSH levels in the muscle tissue were obtained in groups 7 and 8. Conclusion: Results of the study demonstrate that zinc sulfate supplementation has a protective role against lipid peroxidation caused by strenuous swimming exercise in the muscle tissue of diabetic rats. [ABSTRACT FROM AUTHOR]