兰索拉唑联合奥曲肽治疗急性非静脉曲张性上消化道出血的临床效果 及安全性分析

Objective: To analyze the clinical efficacy and safety of lansoprazole combined with octreotide in the treatment of acute non variceal upper gastrointestinal bleeding. Methods: 102 cases of patients with acute non-variceal upper gastrointestinal bleeding treated in our hospital from January 2014 to January 2017 were selected and randomly divided into group A. group B and group C, 34 cases in each group. Group A was treated with lansoprazole, group B was treated with octreotide, and group C was treated with lansoprazole and octreotide. The clinical efficacy, hemostasis time, blood pressure stability time, volume of gastric drainage. PH value of gastric fluid and incidence of adverse reactions were compared between the three groups. Results: After treatment, the apparent effective rate of group C was 61.76%. which was significantly higher than that of group A and group B (P<0.05). The total effective rate of group C was 97.06%. which was significantly higher than that of group B (P<0.05). The hemostasis time of group C was (15.37± 4.38) h. the blood pressure stability tune was (7.23± 1.18) h. the volume of gastric drainage was (236.59 ± 29.81) mL. which were significantly lower than those of group A and group B. The PH value of gastric fluid of group C was (5.91± 0.57). which was significantly higher than that of group A and group B (P=0.05). The incidence of adverse reactions of three groups showed no statistically significant difference(P=0.05). Conclusion: Lansoprazole combined with octreotide could significantly improve the hemostatic effect in the treatment of acute non variceal upper gastrointestinal bleeding. The clinical effect is much better than the single use of lansoprazole or octreotide, and the safety is quite. [ABSTRACT FROM AUTHOR]