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Cytotoxicity of abietane diterpenoids from Salvia multicaulis towards multidrug-resistant cancer cells.
- Source :
-
Fitoterapia . Oct2018, Vol. 130, p54-60. 7p. - Publication Year :
- 2018
-
Abstract
- Abstract Diterpenoids salvimulticanol (1) and salvimulticaoic acid (2) together with known diterpenoid (3–6) were isolated from Salvia multicaulis. Structures were elucidated by spectroscopic techniques including HRESIMS as well as 1D-, and 2D-NMR. In-vitro cytotoxicity was assayed against human cancer cell lines. As several metabolites exhibited activity against drug-resistance lines, compounds were screened against a panel of human drug-sensitive and multidrug-resistant cancer lines. A proposed biosynthetic pathway for these new diterpenoids (1 – 2) as well as the cytotoxic structure-activity relationship of all identified compounds were discussed. Compound 1 and 6 showed the most potent cytotoxicity with IC 50 11.58 and 4.13 towards leukemia cell lines CCRF-CEM and CEM-ADR5000, respectively. Graphical abstract Unlabelled Image [ABSTRACT FROM AUTHOR]
- Subjects :
- *BIOLOGICAL assay
*CELL culture
*CELL death
*CELL lines
*CHROMATOGRAPHIC analysis
*DRUG resistance in cancer cells
*HIGH performance liquid chromatography
*MASS spectrometry
*MOLECULAR structure
*NUCLEAR magnetic resonance spectroscopy
*TERPENES
*THIN layer chromatography
*PLANT extracts
*IN vitro studies
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 130
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 132391503
- Full Text :
- https://doi.org/10.1016/j.fitote.2018.08.002