No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found

Given the remarkable similarities between the genetics of tau diseases and the genetics of α-synuclein diseases, and given the fact that we have recently found a triplication of the α-synuclein locus in a family in which we had shown linkage to the α-synuclein locus, we determined to test whether some of the several families with autosomal dominant frontal temporal dementia which show genetic linkage to the tau locus but in which tau mutations have not been found could be caused by similar structural mutations. We did not find any such mutations. [Copyright &y& Elsevier]