25.4 Stimulants or Nonstimulants for ADHD: What Can Results From a Head-To-Head Comparator Crossover Study Teach Us About Treatment Algorithms?

Current treatment algorithms recommend stimulants as the first medication option for youth with ADHD, unless there are mitigating circumstances in which case they would switch to a different stimulant or nonstimulant if treatment is unsuccessful. We compared methylphenidate (MPH) and atomoxetine (ATX) in a randomized, double-blind, cross-over study (3-6 weeks of each medication, separated by a 2-week placebo washout). [Extracted from the article]