7.2 High Times for Cannabis: Epigenetic Imprint and Its Legacy on Brain and Behavior.

The reduced perception regarding risks associated with marijuana (Cannabis sativa), as well as the growing industry evolving around recreational and medical cannabis, has led to increased use of the drug, and is now used to a greater extent than cigarettes by adolescents. We focus on SP 9 sp -tetrahydrocannabinol (THC) because it is the predominant cannabinoid in the cannabis plants most commonly consumed. In addition, our research provides evidence that parental THC exposure leads to abnormal reward-seeking behavior, as well as neurophysiological and epigenetic alterations in the offspring. [Extracted from the article]