In vitro degradation behavior of Mg scaffolds with three-dimensional interconnected porous structures for bone tissue engineering.

Graphical abstract Highlights • Two three-dimensional interconnected Mg scaffolds were evaluated by immersion. • The interconnectivity of both scaffolds was gradually inhibited by the deposition. • The internal pores struts degraded slower compared with the external pore struts. • The cambered pore struts degraded faster than the polygonal pore struts. Abstract The degradation behavior in consideration of the pore strut and the interconnectivity of two Mg scaffolds with different three-dimensional interconnected porous structures were evaluated. The interconnectivity of the two scaffolds gradually decreased along with the clogged interconnected pores due to the deposition formation on the pore wall. Mg scaffold with spherical pores and cambered pore strut degraded faster but exhibited better resistance to the deterioration of the interconnectivity compared with Mg scaffold with irregular pores and polygonal pore struts. Direct cell culture of MC3T3-E1 osteoblasts on the two scaffolds indicated a promising potential for bone tissue engineering. [ABSTRACT FROM AUTHOR]