SSRIs in the medical subspecialty clinic: Part two.

Back in the March 2018 issue, I wrote a commentary titled "Why Don't SSRIs Work in the Medical Subspecialty Clinic?" The stimulus for this was our coverage that month of the results of the Chronic Kidney Disease Antidepressant Sertraline Trial, which found that sertraline was no better than placebo for depressive symptoms in patients with chronic kidney disease and major depression. I described the findings as "disappointing," and although I intended to convey that disappointment in the title of the commentary, perhaps I erred a bit on the nihilistic side. Happily, a paper we are covering this month allows me to offer a corrective. [ABSTRACT FROM AUTHOR]