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Distinct modulation of group I ribozyme activity among stereoisomers of a synthetic pentamine with structural constraints.
- Source :
-
Biochemical & Biophysical Research Communications . Oct2018, Vol. 504 Issue 4, p698-703. 6p. - Publication Year :
- 2018
-
Abstract
- Abstract Among cationic molecules that can modulate ribozyme activities, polyamines act as both activator and inhibitor of ribozyme reactions partly due to their structural flexibility. Restriction of structural flexibility of polyamines may allow them to emphasize particular modulation effects. We examined eight stereoisomers of a synthetic pentamine bearing three cyclopentane rings. In the reaction of a structurally unstable group I ribozyme, three stereoisomers exhibited distinct effects as inhibitor, an additive with a neutral effect, and also as an activator. Highlights • Three stereoisomers of a pentamine showed distinct effects on a group I ribozyme. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CATALYTIC RNA
*STEREOISOMERS
*POLYAMINES
*CYCLOPENTANE
*ALIPHATIC amines
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 504
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 132095012
- Full Text :
- https://doi.org/10.1016/j.bbrc.2018.09.015