Treatment failure of direct oral anticoagulants in anti-phospholipid syndrome.

The article presents three case studies regarding the inefficacy of the use of dabigatran for prophylaxis of thromboembolismin patients with anti-phospholipid syndrome (APS). One of the women had two subsequent right-sided cerebral infarcts and was treted with dabigatran on suspicion of paroxysmal atrial fibrillation.