Electrochemical Determination of Paracetamol at Poly(3-Methylthiophene)/Reduced Graphene Oxide Modified Glassy Carbon Electrode.

Poly(3-methylthiophene)/reduced graphene oxide (P3MT/RGO) modified glassy carbon electrode (GCE) was fabricated via a facile procedure. P3MT was directly electrodeposited on the RGO coated electrode and employed for the electrochemical detection of paracetamol (PCT). The morphology of composite was characterized by scanning electron microscopy (SEM). Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were used to investigate the electrochemical behaviors of PCT on P3MT/RGO/GCE. Experimental parameters, such as the scan rates, polymerization laps and the pH of buffer solution were optimized. Under the optimal conditions, the anodic peak current in DPVs varies linearly with the concentration of PCT, and the limit of detection was 0.025 μ M. Moreover, the proposed P3MT/RGO/GCE also exhibited superior stability and reproducibility. The poly (3-methylthiophene)/reduced graphene oxide (P3MT/RGO) material was firstly proposed for the fast, sensitive electrochemical determination of paracetamol (PCT). The RGO can efficiently provide abundant reaction sites and promote the electron transfer, while the P3MT was electrodeposited on the surface of RGO/GCE. The redox current response increased further and the reversibility of the redox reaction was improved. The developed sensor showed excellent stability, high selectivity, low detection limit and good applicability in real samples. [ABSTRACT FROM AUTHOR]