Molecular encapsulator–appended poly(vinyl alcohol) shroud on ferrite nanoparticles. Augmented cancer–drug loading and anticancer property.

Abstract Magnetic nanoparticles (MNPs) have the potency to deliver cancer drugs assisted by the application of a magnetic field. In this paper, we present the design of magnesium ferrite nanoparticles of size suitable for drug delivery. A coating polymer, poly(vinyl alcohol), tethered with a tapered cone-shaped cyclic oligosachcharide, β-cyclodextrin (β-CD) is synthesized and used to wrap and disperse the MNPs. The magnetic properties are explored using vibrating sample magnetometry and Mössbauer spectroscopy. The ∑130 nm MNPs, shrouded with the PVA-CD conjugate allows a high amount of the cancer drug, camptothecin, to be loaded on the nanocarrier. Cytotoxicity studies reveal that the loaded drug retains its potency against HEK 293 cells and the cells are sensitive to the treatment by the drug-loaded nanocarrier. Graphical abstract Unlabelled Image Highlights • Magnesium ferrite nanoparticles with high magnetization value are prepared. • β-Cyclodextrin-tethered PVA polymer is prepared and coated on the nanoparticles. • High percentage of drug loading is attained using the nanocarrier. • The anticancer activity of the drug loaded magnetic nanocarrier is studied on HCT-15 prostatic cancer cells. • The ferrite-modified PVA hybrid nanoparticles function well as camptothecin carriers. [ABSTRACT FROM AUTHOR]