Back to Search
Start Over
Existence of Compensatory Defense Mechanisms Against Oxidative Stress and Hypertension in Preeclampsia.
Existence of Compensatory Defense Mechanisms Against Oxidative Stress and Hypertension in Preeclampsia.
- Source :
-
Hypertension in Pregnancy . Mar2010, Vol. 29 Issue 1, p21-37. 17p. 3 Charts, 3 Graphs. - Publication Year :
- 2010
-
Abstract
- Objective: Preeclampsia is a complex obstetrical syndrome characterized by hypertension and proteinuria. This syndrome is associated with oxidative stress, antioxidant imbalance and impaired production of vasoactive eicosanoids such as thromboxane A2 (TXA2), a potent vasoconstrictor, and prostacyclin (PGI2), a well-known vasodilator. We hypothesized that there was a relationship between antioxidant vitamins, such as vitamin E and coenzyme Q10 (CoQ10), and the production of vasoactive eicosanoids— PGI2 and TXA2—potentially regulated by pro-oxidants and antioxidants in preeclampsia. Methods: Therefore, the plasma levels of vitamin E, CoQ10, TXA2 and PGI2 in normotensive (n = 30) and preeclamptic (n = 29) pregnancies were evaluated. Reduced and oxidized forms of vitamin E and CoQ10 in blood were measured using a HPLC coupled to electrochemical detection. The levels of TXB2 and 6-keto-PGF1α, stable metabolites of TXA2 and PGI2 respectively, were measured by ELISA. Results: The CoQ10 oxidized/reduced ratio was significantly higher in preeclamptic compared to normotensive pregnancies (p = 0.04). A strong correlation between plasma levels of reduced vitamin E and CoQ10, corrected for apolipoprotein B, was observed only in preeclampsia (r = 0.69, p < 0.0001). The 6-keto-PGF1α/TXB2 ratio was higher in preeclampsia than in controls (p = 0.02), and this ratio was correlated to the oxidized/reduced ratio of both, vitamin E and CoQ10 in all pregnancies (p <0.023). Conclusion: The data indicated that CoQ10 is a sensitive marker of oxidative stress in preeclampsia. The correlation between vitamin E and CoQ10 suggested a coordinated defense mechanism against oxidation. Furthermore, the higher 6-keto-PGF1α/TXB2 ratio that strongly correlated with oxidative stress markers, suggests a mechanism developed by the maternal cardiovascular system to counteract hypertension during preeclampsia. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10641955
- Volume :
- 29
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Hypertension in Pregnancy
- Publication Type :
- Academic Journal
- Accession number :
- 131918305
- Full Text :
- https://doi.org/10.3109/10641950902777689