整合素和 E-钙黏素在诱导多能干细胞重编程及干性维持中的作用.

BACKGROUND: Induced pluripotent stem cells (iPSCs) hold enormous potential as a tool to generate cells for disease modeling and regenerative medicine. The premise for clinical application of iPSCs is the efficient reprogramming of somatic cells to iPSCs. In recent years, increasing studies have demonstrated that integrins and E-cadherin play important roles in the reprogramming and maintenance of iPSCs. Investigations on the underlying molecular mechanism will help us developing safer and more efficient reprogramming methods for iPSCs generation and deeply understanding the reprogramming process. OBJECTIVE: To summarize the effect of integrins and E-cadherin on the reprogramming of iPSCs and the maintenance of pluripotency based on the insights into the underlying molecular mechanisms. METHODS: Scientific papers published from 2006 to present that described the effects of cell adhesion on reprogramming and stemness maintenance of iPSCs were retrieved by the first author in the Web of Science. Sixty-three articles related to the purpose of this review were reviewed. RESULTS AND CONCLUSION: Integrins-mediated cell-matrix adhesion and E-cadherin-mediated cell-cell adhesion can regulate pluripotent gene expression through a variety of downstream signaling pathways, and can also play important roles in the organization and contractility of actin cytoskeletons that generate gene-, protein-, and epigenetic-level changes and ultimately influence cell reprogramming and stemness maintenance. [ABSTRACT FROM AUTHOR]