Cartilage diseases.

Abstract Hyaline cartilages, fibrocartilages and elastic cartilages play multiple roles in the human body including bearing loads in articular joints and intervertebral discs, providing joint lubrication, forming the external ears and nose, supporting the trachea, and forming the long bones during development and growth. The structure and organization of cartilage's extracellular matrix (ECM) are the primary determinants of normal function. Most diseases involving cartilage lead to dramatic changes in the ECM which can govern disease progression (e.g., in osteoarthritis), cause the main symptoms of the disease (e.g., dwarfism caused by genetically inherited mutations) or occur as collateral damage in pathological processes occurring in other nearby tissues (e.g., osteochondritis dissecans and inflammatory arthropathies). Challenges associated with cartilage diseases include poor understanding of the etiology and pathogenesis, delayed diagnoses due to the aneural nature of the tissue and drug delivery challenges due to the avascular nature of adult cartilages. This narrative review provides an overview of the clinical and pathological features as well as current treatment options available for various cartilage diseases. Late breaking advances are also described in the quest for development and delivery of effective disease modifying drugs for cartilage diseases including osteoarthritis, the most common form of arthritis that affects hundreds of millions of people worldwide. Highlights • Cartilage diseases range from extremely rare conditions (three cases worldwide) to the most common, Osteoarthritis (OA) • Dramatic extracellular matrix changes in these diseases impair normal tissue function and lead to disease progression • There are no disease modifying drugs available for osteoarthritis • Potential disease modifying OA drugs (DMOADs) are being developed based on new advances in understanding OA pathogenesis • Cartilage-targeted drug delivery can potentially transform unsuccessful DMOAD candidates into effective therapeutics [ABSTRACT FROM AUTHOR]