Carbapenem-Sparing Therapy for Extended-Spectrum β-Lactamase-Producing E coli and Klebsiella pneumoniae Bloodstream Infection: The Search Continues.

The author discusses research by P. N. A. Harris and colleagues that compared the effects of piperacillin-tazobactam versus meropenem on mortality of patients with Escherichia coli or Klebsiella pneumoniae bloodstream infection and ceftriaxone resistance. Topics covered include strengths and weaknesses of the study, resistance to piperacillin-tazobactam, and implications for clinicians, clinical microbiologists, and antibiotic stewards.