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Providing hyper-branched dendrimer conjugated with β-cyclodextrin based on magnetic nanoparticles for the separation of methylprednisolone acetate.

Authors :
Baimani, Nasim
Aberoomand Azar, Parviz
Husain, Syed Waqif
Ahmad Panahi, Homayon
Mehramizi, Ali
Source :
Journal of Chromatography A. Oct2018, Vol. 1571, p38-46. 9p.
Publication Year :
2018

Abstract

Highlights • Efficient method for the extraction of the anti-inflammatory drug by nano-sorbent. • Representing excellent linearity, recovery, LOD and RSD by SPE technique with HPLC. • Developed method for dendritic β-CD in order to obtain high sorption capacity. Abstract This study introduced a developed approach for dendritic β-cyclodextrin (β-CD) in order to obtain high sorption capacity. Synthetic strategy exploits the reactivity between acrylic acid and allyl glycidyl ether for high-yielding assembly via grafting on to the magnetic nanoparticles that are modified using 3-mercaptopropyltrimethoxysilane for various building branches and host–guest molecules of β-CD. The methodology has been applied for the preparation of a series of β-CD conjugated magnetic nanoparticles with dendrimers as a nano-sorbent for the extraction of methylprednisolone acetate. This study allowed us to probe (i) the effects of the dendric-cyclodextrin architecture on the affinity of sorption capacity, (ii) the drug influence between the cyclodextrin core and the polyester dendrimer, and (iii) the result of sorbent formation for using the anti-inflammatory drug as a target guest into the ring of β-CD on biological extraction. It was found that the adsorption behavior could be fitted by the Langmuir adsorption isotherm model. The adsorption capacity of MPA is found to be 12.4 mg g−1 and indicated the homogeneous sites onto polymer grafted magnetite nano-sorbent surface. Our results confirm the high capability of this type of dendrimer-β-CD for drug extraction in biological fluids and pharmaceutical samples. This nano-sorbent assists the magnetic solid phase extraction technique represented in the high extraction yield (up to 97%) for methylprednisolone acetate in biological human fluids and pharmaceutical samples. Moreover, the achieved polymeric nano-sorbent of the reaction combination was facilitated by a magnetic field and reusability was performed without any notable loss in the sorbent activity. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00219673
Volume :
1571
Database :
Academic Search Index
Journal :
Journal of Chromatography A
Publication Type :
Academic Journal
Accession number :
131730994
Full Text :
https://doi.org/10.1016/j.chroma.2018.08.005