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Analysis of nitrofuran metabolic residues in salt by liquid chromatography–tandem mass spectrometry
- Source :
-
Analytica Chimica Acta . Jun2004, Vol. 514 Issue 1, p9-13. 5p. - Publication Year :
- 2004
-
Abstract
- Recent reports from the Brazilian Agricultural Ministry program of residue control describe some cases of the presence of semicarbazide, the target metabolite of nitrofurazone {2-[(5-nitro-2-furanyl)methylene]-hydrazinecarboxamide}, in samples of salted chicken meat. Since that contamination can be originated from other reasons in addition to nitrofurazone abuse, our laboratory has developed a sensitive and simple method for detection of four nitrofuran metabolites in salt samples. This method include a previous hexane extraction of the metabolites followed by a derivatization reaction with 2-nitrobenzaldehyde. The nitrophenyl derivatives were analyzed by liquid chromatography–tandem mass spectrometry without any additional clean-up procedures. The limit of quantification for routine analysis was 0.5 μg kg-1 for each metabolite. [Copyright &y& Elsevier]
- Subjects :
- *NITROFURANS
*LIQUID chromatography
*SPECTRUM analysis
*ANIMAL products
Subjects
Details
- Language :
- English
- ISSN :
- 00032670
- Volume :
- 514
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Analytica Chimica Acta
- Publication Type :
- Academic Journal
- Accession number :
- 13167225
- Full Text :
- https://doi.org/10.1016/j.aca.2004.03.033