Back to Search
Start Over
Ultrasensitive photoelectrochemical immunosensor for the detection of amyloid β-protein based on SnO2/SnS2/Ag2S nanocomposites.
- Source :
-
Biosensors & Bioelectronics . Nov2018, Vol. 120, p1-7. 7p. - Publication Year :
- 2018
-
Abstract
- Abstract An ultrasensitive label-free photoelectrochemical (PEC) immunosensor with high visible-light activity was developed for quantitative detection of amyloid β-protein (Aβ) by cross-linking anti-Aβ antibody onto the Ag 2 S sensitized SnO 2 /SnS 2 nanocomposites. Specifically, SnO 2 with flower-like porous nanostructure was innovatively applied in PEC immunosensor as a basal material. It could form a heterostructure with SnS 2 , which brought about the sensitization of SnO 2 and enhanced the separation of photogenerated electrons and holes. Moreover, Ag 2 S was in-situ growth on the surface of SnO 2 /SnS 2 , which further enhanced the photocurrent response significantly. Therefore, SnO 2 /SnS 2 /Ag 2 S could form stepwise band-edge structure, which benefited the light harvesting and provided a good foundation for sensor construction and detection. Under optimal conditions, the PEC immunosensor was used to detect the content of Aβ and exhibited a wide linear concentration range from 0.5 pg mL−1 to 100 ng mL−1, with low limit of detection (0.17 pg mL−1) and limit of quantification (0.56 pg mL−1). Additionally, the designed PEC immunosensor exhibited good reproducibility, specificity, and stability which may find potential applications in the biosensor, biomedicine, clinical diagnosis, photocatalysis and other related fields. Highlights • A label-free PEC immunosensor was developed based on SnO 2 /SnS 2 /Ag 2 S nanocomposites. • SnO 2 /SnS 2 /Ag 2 S nanocomposites exhibited excellent photoelectrochemical performance. • The PEC immunosensor displayed highly sensitive detection toward amyloid β-protein. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09565663
- Volume :
- 120
- Database :
- Academic Search Index
- Journal :
- Biosensors & Bioelectronics
- Publication Type :
- Academic Journal
- Accession number :
- 131664286
- Full Text :
- https://doi.org/10.1016/j.bios.2018.08.026