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D-lactic Acidosis: Successful Suppression of D-lactate--Lactobacillus Producing.
- Source :
-
Pediatrics . Sep2018, Vol. 142 Issue 3, p1-5. 5p. - Publication Year :
- 2018
-
Abstract
- Intestinal microbiota composition in children with short bowel syndrome (SBS) is an important factor influencing the clinical outcome. An increase of D-lactate--producing bacteria can lead to D-lactic acidosis, also referred to as D-lactate encephalopathy, with severe neurologic impairment. Antibiotic treatments for D-lactic acidosis in children with SBS offer often only short- term relief. Here, we present the case of a boy with SBS who developed recurrent episodes of D-lactic acidosis even under continuous cycling antibiotic treatment. Microbiological analyses were used to detect the presence of D-lactate--producing Lactobacillus species in the stool samples. A probiotic cocktail was introduced to alter the intestinal microbiota. During follow-up under treatment with probiotics, the patient remained stable, and there was no additional need for antibiotic therapy for more than a year. Stool composition of the patient was sequenced regularly over that period. His microbiota profile changed completely in species richness, and a clustering of species according to probiotic usage was seen. Importantly, D-lactate--producing Lactobacillus strains disappeared within a few weeks after probiotic introduction and were no longer detected in the subsequent follow-up specimens. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00314005
- Volume :
- 142
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 131612817
- Full Text :
- https://doi.org/10.1542/peds.2018-0337