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Onconeural antigen spreading in paraneoplastic neurological disease due to small cell lung cancer.
- Source :
-
Oxford Medical Case Reports . 2018, Vol. 2018 Issue 7, pN.PAG-N.PAG. 1p. - Publication Year :
- 2018
-
Abstract
- Cellular and humoral immunity towards distinct onconeural antigens is the hallmark of paraneoplastic neurological diseases (PNDs). Stable formation of immunoglobulin (Ig) G antibodies to particular onconeural antigens occurs in the majority of cases, whereas persistent coexistence of antibodies specific for multiple onconeural antigens is a relatively rare phenomenon of certain malignant tumors like small cell lung cancer (SCLC). We here describe onconeural antigen spreading in a 70-year-old Caucasian male with PND due to SCLC. Onconeural antigen spreading may be promoted by two mutually non-exclusive mechanisms: (i) a switch of antigen expression pattern of the underlying tumor tissue as a result of a mutagenic process caused by the cancer itself and (ii) a self-propagated paraneoplastic immune response with persistent neuronal destruction, liberation, processing and presentation of intracellular neural antigens. This illustrates a potential dissociation between peripheral anti-tumoral immunity and central anti-neural immunity during the course of PND. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20538855
- Volume :
- 2018
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Oxford Medical Case Reports
- Publication Type :
- Academic Journal
- Accession number :
- 131510271
- Full Text :
- https://doi.org/10.1093/omcr/omy034