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A Single Locus Controls Interferon Gamma-Independent Antiretroviral Neutralizing Antibody Responses.
- Source :
-
Journal of Virology . Aug2018, Vol. 92 Issue 16, p1-13. 13p. - Publication Year :
- 2018
-
Abstract
- An essential step in the development of effective antiviral humoral responses is cytokine-triggered class switch recombination resulting in the production of antibodies of a specific isotype. Most viral and parasitic infections in mice induce predominantly IgG2a-specific antibody responses that are stimulated by interferon gamma (IFN-γ). However, in some mice deficient in IFN-γ, class switching to IgG2a antibodies is relatively unaffected, indicating that another signal(s) can be generated upon viral or parasitic infections that trigger this response. Here, we found that a single recessive locus, provisionally called IFN-γ-independent IgG2a (Igii), confers the ability to produce IFN-γ-independent production of IgG2a antibodies upon retroviral infection. The Igii locus was mapped to chromosome 9 and was found to function in the radiation-resistant compartment. Thus, our data implicate nonhematopoietic cells in activation of antiviral antibody responses in the absence of IFN-γ. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INTERFERON gamma
*CYTOKINES
*IMMUNOGLOBULIN G
*RETROVIRUS diseases
*CELL receptors
Subjects
Details
- Language :
- English
- ISSN :
- 0022538X
- Volume :
- 92
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- Journal of Virology
- Publication Type :
- Academic Journal
- Accession number :
- 131123305
- Full Text :
- https://doi.org/10.1128/JVI.00725-18