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In vivo study of enhanced chemotherapy combined with ultrasound image-guided focused ultrasound (USgFUS) treatment for pancreatic cancer in a xenograft mouse model.
- Source :
-
European Radiology . Sep2018, Vol. 28 Issue 9, p3710-3718. 9p. 2 Color Photographs, 1 Chart, 4 Graphs. - Publication Year :
- 2018
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Abstract
- <bold>Objectives: </bold>This study was designed to investigate whether focused ultrasound (FUS) treatment with a higher mechanical index (MI) can enhance the effects of combined chemotherapy more than with a lower MI, and to evaluate the feasibility of the chemotherapy combined with FUS at a higher MI as an alternative treatment protocol.<bold>Methods: </bold>Mice in the first study were divided into six groups: control, chemotherapy only (GEM), two groups treated with FUS only at two different MIs, and two groups treated with chemotherapy and FUS (GEM + FUS). Mice were treated with a single-session treatment; one session consisted of three weekly treatments and 1 week of follow-up monitoring. In the second study, mice were assigned to two groups (GEM, GEM + FUS) and treated with four treatment sessions.<bold>Results: </bold>In the single-session treatment, tumor growth was most effectively suppressed in GEM + FUS group with a higher MI. Tumor growth rate was significantly lower in GEM + FUS group than in GEM group for multiple-session treatment. Specifically, three of ten mice in GEM + FUS group showed complete remission.<bold>Conclusions: </bold>This study demonstrated that FUS at a higher MI can enhance chemotherapy outcomes more than at a lower MI and demonstrated the potential of FUS in combination with chemotherapy as a new cancer treatment protocol.<bold>Key Points: </bold>• Combined treatment of chemotherapy and focused ultrasound can effectively suppress tumor growth. • For the focused ultrasound treatment conditions used in this study, focused ultrasound with relatively higher mechanical index shows more enhanced therapeutic outcomes than with the lower mechanical index. • Combination therapy shows the possibility as a new cancer treatment protocol. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PANCREATIC cancer diagnosis
*PANCREATIC cancer treatment
*CANCER chemotherapy
*XENOGRAFTS
*ULTRASONIC imaging
*LABORATORY mice
*ANIMAL experimentation
*ANIMALS
*BIOLOGICAL models
*COMBINED modality therapy
*MICE
*PANCREAS
*PANCREATIC tumors
*RESEARCH funding
*ULTRASONIC therapy
*PILOT projects
*TREATMENT effectiveness
*TUMOR treatment
Subjects
Details
- Language :
- English
- ISSN :
- 09387994
- Volume :
- 28
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- European Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 131115223
- Full Text :
- https://doi.org/10.1007/s00330-018-5355-9