Evaluation of Adverse Drug Allergy in Patient's Admitted in Shahid Sadoughi Hospital, Yazd 2011-2014.

Objective: Drug reactions are common and can be dangerous. 6 to 10 percent of drug reactions are allergic which can be fatal in some cases. In many cases, adverse drug reactions are predictable and can be prevented. Regarding to the points that there was not any study in the field of drug reactions in the Yazd University of Medical Sciences, we aimed to evaluate that. Identifying of drug reaction prevalence and common culprit drugs will help researchers in future studies in this filled to plan for prevention of them. Material and Methods: In a retrospective descriptive study, records of patients who were admitted in shahid sadoughi hospital due to drug reaction from 2011 to 2014 were evaluated. Patient's information such as gender, age, occurred drug reaction, type of drug allergy, duration of hospital stays and the time of drug reaction after drug usage completed in the data form collection. Results: From 154 cases which admitted with adverse drug reaction, 77 cases (50%) were related to drug allergies and 13 (4.8 percent) were drug complications and 64 cases (41.6 %) were drug toxicity. 78 patients were male (50.6 percent) and 76 (49.4 percent) patients were female. 64 patients (41.6 percent) were less than 6 years and 28 patients (18.2%) were 6 to 14 years and 62 patients (40.3 %) were adults. Antiepileptic drugs were the most common causes of drug reactions (31.2 percent) of which the most common drug was lamotrigine (15.6 percent). Drug allergies were categorized in type I, 12 patients (8.7%), type II no case, type III, 9 patients (8.5%) and type, 56 patients (36.8 percent). Finally, five deaths were reported due to drug reaction. Conclusion: Adverse drug reaction was common and remarkable in shahid sadoughi hospitals and from 2011 to 2014 its prevalence had increased. General physicians must be aware of these reactions to evaluate patients with immediate and severe reactions. Reduce the consumption of medication without prescription may also be useful in preventing drug reactions. [ABSTRACT FROM AUTHOR]