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Evaluation of a Booster Dose of Pentavalent Rotavirus Vaccine Coadministered With Measles, Yellow Fever, and Meningitis A Vaccines in 9-Month-Old Malian Infants.
- Source :
-
Journal of Infectious Diseases . 8/15/2018, Vol. 218 Issue 4, p606-613. 8p. - Publication Year :
- 2018
-
Abstract
- <bold>Background: </bold>Rotavirus vaccines given to infants are safe and efficacious. A booster dose of rotavirus vaccine could extend protection into the second year of life in low-resource countries.<bold>Methods: </bold>We conducted an open-label, individual-randomized trial in Bamako, Mali. We assigned 600 infants aged 9-11 months to receive measles vaccine (MV), yellow fever vaccine (YFV), and meningococcal A conjugate vaccine (MenAV) with or without pentavalent rotavirus vaccine (PRV). We assessed the noninferiority (defined as a difference of ≤10%) of seroconversion and seroresponse rates to MV, YFV, and MenAV. We compared the seroresponse to PRV.<bold>Results: </bold>Seroconversion to MV occurred in 255 of 261 PRV recipients (97.7%) and 246 of 252 control infants (97.6%; difference, 0.1% [95% confidence interval {CI}, -4.0%-4.2%]). Seroresponse to YFV occurred in 48.1% of PRV recipients (141 of 293), compared with 52.2% of controls (153 of 293; difference, -4.1% [95% CI, -12.2%-4.0%]). A 4-fold rise in meningococcus A bactericidal titer was observed in 273 of 292 PRV recipients (93.5%) and 276 of 293 controls (94.2%; difference, -0.7% [95% CI, -5.2%-3.8%]). Rises in geometric mean concentrations of immunoglobulin A and immunoglobulin G antibodies to rotavirus were higher among PRV recipients (118 [95% CI, 91-154] and 364 [95% CI, 294-450], respectively), compared with controls (68 [95% CI, 50-92] and 153 [95% CI, 114-207], respectively).<bold>Conclusions: </bold>PRV did not interfere with MV and MenAV; this study could not rule out interference with YFV. PRV increased serum rotavirus antibody levels.<bold>Clinical Trials Registration: </bold>NCT02286895. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ROTAVIRUS vaccines
*IMMUNIZATION
*IMMUNOTHERAPY
*THERAPEUTICS
*VACCINES
*MENINGITIS
*IMMUNOGLOBULIN analysis
*RESEARCH
*IMMUNOGLOBULINS
*RETROVIRUS diseases
*RESEARCH methodology
*MALIANS
*BACTERIAL antibodies
*EVALUATION research
*MENINGOCOCCAL vaccines
*COMPARATIVE studies
*DRUG interactions
*RESEARCH funding
*MEASLES vaccines
*YELLOW fever vaccines
*VIRAL antibodies
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 218
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 130875134
- Full Text :
- https://doi.org/10.1093/infdis/jiy215