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Perspectives for personalized therapy for patients with multidrug-resistant tuberculosis.

Authors :
Lange, C.
Alghamdi, W. A.
Al‐Shaer, M. H.
Brighenti, S.
Diacon, A. H.
DiNardo, A. R.
Grobbel, H. P.
Gröschel, M. I.
von Groote‐Bidlingmaier, F.
Hauptmann, M.
Heyckendorf, J.
Köhler, N.
Kohl, T. A.
Merker, M.
Niemann, S.
Peloquin, C. A.
Reimann, M.
Schaible, U. E.
Schaub, D.
Schleusener, V.
Source :
Journal of Internal Medicine. Aug2018, Vol. 284 Issue 2, p163-188. 26p. 3 Diagrams, 6 Charts, 1 Graph.
Publication Year :
2018

Abstract

According to the World Health Organization (WHO), tuberculosis is the leading cause of death attributed to a single microbial pathogen worldwide. In addition to the large number of patients affected by tuberculosis, the emergence of Mycobacterium tuberculosis drug-resistance is complicating tuberculosis control in many high-burden countries. During the past 5 years, the global number of patients identified with multidrug-resistant tuberculosis (MDR-TB), defined as bacillary resistance at least against rifampicin and isoniazid, the two most active drugs in a treatment regimen, has increased by more than 20% annually. Today we experience a historical peak in the number of patients affected by MDR-TB. The management of MDR-TB is characterized by delayed diagnosis, uncertainty of the extent of bacillary drug-resistance, imprecise standardized drug regimens and dosages, very long duration of therapy and high frequency of adverse events which all translate into a poor prognosis for many of the affected patients. Major scientific and technological advances in recent years provide new perspectives through treatment regimens tailor-made to individual needs. Where available, such personalized treatment has major implications on the treatment outcomes of patients with MDR-TB. The challenge now is to bring these adances to those patients that need them most. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09546820
Volume :
284
Issue :
2
Database :
Academic Search Index
Journal :
Journal of Internal Medicine
Publication Type :
Academic Journal
Accession number :
130817923
Full Text :
https://doi.org/10.1111/joim.12780