Chiral N,N′‐Dioxide/ScΙΙΙ Complex‐Catalyzed Asymmetric Ring‐Opening Reaction of Cyclopropyl Ketones with Indoles.

Abstract: The asymmetric ring‐opening reaction of cyclopropyl ketones with indoles has been realized by using a N,N′‐dioxide/scandium(ΙΙΙ) complex as catalyst. The corresponding 3‐alkylated indole derivatives were obtained in moderate to excellent yields with good ee values. Moreover, a possible transition state was proposed on the basis of experimental studies and X‐ray structure of product. [ABSTRACT FROM AUTHOR]