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Functional State of Cells During their Life and on their Journey Toward Inactivity and Death: Search for Morphological Evidence in Thyroid Fine Needle Aspiration Smears.
- Source :
-
Journal of Cytology . Jul-Sep2018, Vol. 35 Issue 3, p131-138. 8p. - Publication Year :
- 2018
-
Abstract
- Synthesis and storage of thyroglobulin as well as synthesis of thyroid hormones and their release into the circulation are important functions of thyroid, which were studied in fine needle aspiration (FNA) smears from thyroid lesions. Evidence of thyroglobulin synthesis was demonstrated in neoplastic and nonneoplastic follicular cells, especially in Hürthle cells, in the form of colloid inclusions. Whereas the pinocytic vesicles containing colloid at the luminal end of in nonneoplastic and neoplastic follicular cells indicated engulfment of colloid for synthesis of thyroid hormones (T3 and T4), the marginal vacuoles (MVs) (fire-flare appearance) at the basal aspects of follicular cells suggested their release on way to the interfollicular capillaries. The morphological evidence of secretary activity could also be demonstrated in medullary thyroid carcinoma (MTC) in the form of azurophilic granules, marginal vacuoles, and intracytoplasmic lumina (ICL) with secretions; the secretory material, likely to be amyloid, present in MTC cells, and their release to the extracellular space was confirmed by positive immunocytochemical staining for calcitonin. It was found that nuclear grooves and related intranuclear cytoplasmic inclusions (INCIs) in papillary thyroid carcinoma (PTC) possibly represent an initial step of a degenerative process leading to formation of inactive cerebriform nuclei. Based on observation regarding formation and release of precursor substances for psammoma bodies (PBs), it was also suggested that PBs may not represent a process of dystrophic calcification over infarcted/dead papillae but suggest an active biological process, which leads to inhibition of growth of neoplastic cells and acts as a barrier against spread of PTC. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CALCITONIN
*COLLOIDS in medicine
*PLANT vacuoles
*CELL death
*THYROID diseases
*GENETICS
*CELL physiology
*EPITHELIAL cells
*EXTRACELLULAR space
*GLOBULINS
*IMMUNOHISTOCHEMISTRY
*METASTASIS
*NEEDLE biopsy
*STAINS & staining (Microscopy)
*THYROID gland tumors
*THYROID hormones
*PAPILLARY carcinoma
*PHENOBARBITAL
THYROID disease diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 09709371
- Volume :
- 35
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Cytology
- Publication Type :
- Academic Journal
- Accession number :
- 130685684
- Full Text :
- https://doi.org/10.4103/JOC.JOC_43_18