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Synthesis and Spectroscopic Characterization of Some Hydrazone and 2H‐benzopyranone Derivatives as Antitumor Agents.
- Source :
-
Journal of Heterocyclic Chemistry . Jul2018, Vol. 55 Issue 7, p1738-1745. 8p. - Publication Year :
- 2018
-
Abstract
- A new series of hydrazone, 2H‐benzopyranone‐3‐carboxamide and 2H‐benzopyranone‐3‐carbonylthiosemicarbazide derivatives were synthesized from the alkyl 7‐hydroxy‐2H‐benzopyranone‐3‐carboxylate (1a,b) and dibromo derivatives (6a,b) as a key starting materials. The structures of the synthesized new compounds were confirmed by IR, 1H, 13C‐NMR, MS, and elemental analysis. Some hydrazone derivatives and N‐substituted 2H‐benzopyranone‐3‐carboxamides were evaluated for their anticancer activity against HepG‐2 cell lines. Some of these compounds shared good cytotoxicity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0022152X
- Volume :
- 55
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Journal of Heterocyclic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 130670862
- Full Text :
- https://doi.org/10.1002/jhet.3211