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Vinylogous Blaise Reaction: Conceptually New Synthesis of Pyridin-2-ones.
- Source :
-
Synlett . 2018, Vol. 29 Issue 12, p1649-1653. 5p. - Publication Year :
- 2018
-
Abstract
- A conceptually new synthesis of pyridine rings by a [C4 + CN] assembly has been developed by applying a vinylogous version of the classic Blaise reaction. The zinc-mediated reaction of (het)aryl or alkyl nitriles with ethyl-4-bromocrotonate provided a variety of C(6)-substituted pyridin-2-ones in a single-step. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PYRIDINE synthesis
*CROTONATES
*NITRILES
Subjects
Details
- Language :
- English
- ISSN :
- 09365214
- Volume :
- 29
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Synlett
- Publication Type :
- Academic Journal
- Accession number :
- 130651227
- Full Text :
- https://doi.org/10.1055/s-0037-1610171