Effects of marine β-1,3 glucan on immune reactions

Glucans have a long history as nonspecific biological modulators. A novel glucan—Phycarine—was isolated from sporophytes of Laminaria digitata. Phycarine showed significant stimulation of phagocytic activity as well as potentiation of synthesis and release of IL-1, IL-6 and TNF-α. In addition, Phycarine increased NK cell-mediated killing of tumor cells both in vitro and in vivo while acting via complement receptor type 3 (CR3) receptors. [Copyright &y& Elsevier]