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Oximes-induced reactivation of rat brain acetylcholinesterase inhibited by VX agent.
- Source :
-
Human & Experimental Toxicology . Apr2004, Vol. 23 Issue 4, p167-171. 5p. - Publication Year :
- 2004
-
Abstract
- A comparison of one mono- and seven bisquaternary acetylcholinesterase (AChE) reactivators of acetylcholinesterase inhibited by VX agent was performed. As a source of the acetylcholinesterase, a rat brain homogenate was taken. There were significant differences in reactivation potency of all tested oximes. The oxime TO205 seems to be the most efficacious followed by TO046, HI-6, HS-6, K027, obidoxime, MMC and 2-PAM. In addition, the results of this study showed that the reactivation potency of the tested reactivators depends on many factors - such as the number of pyridinium rings, the number of oxime groups and their position, as well as the length and the shape of linkage bridge between two pyridinium rings. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09603271
- Volume :
- 23
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Human & Experimental Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 13054491
- Full Text :
- https://doi.org/10.1191/0960327104ht434oa