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A silver metal complex as a luminescent probe for enzymatic sensing of glucose in blood plasma and urine.
- Source :
-
Dalton Transactions: An International Journal of Inorganic Chemistry . 7/1/2018, Vol. 47 Issue 25, p8346-8355. 10p. - Publication Year :
- 2018
-
Abstract
- In this work, we present a facile preparation of a paper-based glucose assay for rapid, sensitive, and quantitative measurement of glucose in blood plasma and urine. Two copper phosphorescent complexes [Cu(2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline)(2,6-dimethylphenylisocyanide)2][B(C6H3(CF3)2)4] (Cu1) and [Cu(2,9-dimethyl-1,10-phenanthroline)(2,6-dimethylphenylisocyanide)2][B(C6H3(CF3)2)4] (Cu2) and a new silver congener [Ag(P3)CNAg(P3)][B(C6H3(CF3)2)4] (Ag3) (P3 = PPh2C6H4-PPh-C6H4PPh2 [bis(o-diphenylphosphinophenyl)phenylphosphine]) have been synthesized and their oxygen sensing abilities were investigated. The dimetallic phosphine-based Ag3 complex, having a high oxygen sensing ability, was employed as an efficient signal transducer in enzymatic reactions to recognize blood plasma glucose and urine glucose, which provided a wide linear response for a concentration range between 1.0 and 35 mM and a rapid response, with a limit of detection (LOD) of 0.09 mM for glucose. In practical application, this Ag3 paper-based device offers great analytical reliability and accuracy upon monitoring glucose concentrations in blood plasma. [ABSTRACT FROM AUTHOR]
- Subjects :
- *METAL complexes
*SILVER compounds
*GLUCOSE
Subjects
Details
- Language :
- English
- ISSN :
- 14779226
- Volume :
- 47
- Issue :
- 25
- Database :
- Academic Search Index
- Journal :
- Dalton Transactions: An International Journal of Inorganic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 130333382
- Full Text :
- https://doi.org/10.1039/c8dt00500a