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Arabidopsis Serrate Coordinates Histone Methyltransferases ATXR5/6 and RNA Processing Factor RDR6 to Regulate Transposon Expression.
- Source :
-
Developmental Cell . Jun2018, Vol. 45 Issue 6, p769-784.e6. 1p. - Publication Year :
- 2018
-
Abstract
- Summary Serrate (SE) is a key component in RNA metabolism. Little is known about whether and how it can regulate epigenetic silencing. Here, we report histone methyltransferases ATXR5 and ATXR6 (ATXR5/6) as novel partners of SE. ATXR5/6 deposit histone 3 lysine 27 monomethylation (H3K27me1) to promote heterochromatin formation, repress transposable elements (TEs), and control genome stability in Arabidopsis . SE binds to ATXR5/6-regulated TE loci and promotes H3K27me1 accumulation in these regions. Furthermore, SE directly enhances ATXR5 enzymatic activity in vitro . Unexpectedly, se mutation suppresses the TE reactivation and DNA re-replication phenotypes in the atxr5 atxr6 mutant. The suppression of TE expression results from triggering RNA-dependent RNA polymerase 6 (RDR6)-dependent RNA silencing in the se atxr5 atxr6 mutant. We propose that SE facilitates ATXR5/6-mediated deposition of the H3K27me1 mark while inhibiting RDR6-mediated RNA silencing to protect TE transcripts. Hence, SE coordinates epigenetic silencing and RNA processing machineries to fine-tune the TE expression. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ARABIDOPSIS
*HISTONE methyltransferases
*RNA metabolism
*EPIGENETICS
*CHROMATIN
Subjects
Details
- Language :
- English
- ISSN :
- 15345807
- Volume :
- 45
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Developmental Cell
- Publication Type :
- Academic Journal
- Accession number :
- 130303661
- Full Text :
- https://doi.org/10.1016/j.devcel.2018.05.023