Microbial Production of l-Serine from Renewable Feedstocks.

l -Serine is a non-essential amino acid that has wide and expanding applications in industry with a fast-growing market demand. Currently, extraction and enzymatic catalysis are the main processes for l -serine production. However, such approaches limit the industrial-scale applications of this important amino acid. Therefore, shifting to the direct fermentative production of l -serine from renewable feedstocks has attracted increasing attention. This review details the current status of microbial production of l -serine from renewable feedstocks. We also summarize the current trends in metabolic engineering strategies and techniques for the typical industrial organisms Corynebacterium glutamicum and Escherichia coli that have been developed to address and overcome major challenges in the l -serine production process. [ABSTRACT FROM AUTHOR]