THE MECHANISMS OF THE TOXIC EFFECT OF INTRAUTERINE AND EARLY POSTNATAL EXPOSURE TO PESTICIDES ON THE DEVELOPMENT OF THE IMMUNE SYSTEM OF OFFSPRING.

The aim of the study was to identify the mechanisms of the toxic effect of intrauterine and early postnatal exposure to pesticides on the development of the immune system of offspring. Experiments were performed on white adult female rats, which are obtained respectively pesticidescyhalothrinor fipronil during the pregnancy and lactation periods. The offspring from experimental and control animals have been studied on days 3, 7, 14, 21 and 30 days after birth using morphology, electron microscopy, immunohistochemistry and biochemistry methods. In was shown, that the toxic effect of pesticide exposure through the maternal organism during pregnancy and lactation is manifested in the form of a violation of the growth and formation of the thymus, as well as thymusdependent zones of the peripheral organs of the immune system. In the mechanism of immunotoxic effect of pesticides a leading role plays the imbalance between proliferation and cells apoptosis of the thymus, caused both by direct toxic effects of drugs, and by the development of hypothyroidism and oxidative stress. [ABSTRACT FROM AUTHOR]