Monoterpene indole alkaloids from Rhazya stricta.

Twenty-seven monoterpene indole alkaloids (MIAs) including three new ones were isolated from the plant of Rhazya stricta . Their structures were elucidated by analyses of HRMS and NMR data. Secopleiocarpamine A ( 1 ) represents a novel 2,3- seco pleiocarpamine type MIA possessing a cyano group. A possible biosynthetic pathway for 1 was postulated. All compounds were evaluated for their inhibitory activities against six Candida strains, and the results showed that 2 , 5 , 12 , 21 , 23 , and 27 exhibited moderate inhibitory activities with MIC values ranging from 3.125 to 50 μg/mL. [ABSTRACT FROM AUTHOR]