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Soluble Urokinase Plasminogen Activator Receptor (suPAR) as A Predictor of Incident Atrial Fibrillation.
- Source :
-
JAFIB: Journal of Atrial Fibrillation . Apr/May2018, Vol. 10 Issue 6, p1-5. 5p. - Publication Year :
- 2018
-
Abstract
- Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker of chronic low-grade inflammation and a potent predictor of cardiovascular events. We hypothesized that plasma suPAR levels would predict new-onset atrial fibrillation (AF) in a large cohort of consecutively admitted acute medical patients during long-term follow-up. In 14,764 acutely ad-mitted patients without prior or current AF, median suPAR measured upon admission was 2.7 ng/ml (interquartile range (IQR) 1.9-4.0). During a median follow-up of 392 days (IQR 218-577), 349 patients (2.4%) were diagnosed with incident AF. suPAR levels at admission significantly predicted subsequent incident AF (HR per doubling of suPAR: 1.21, 95% CI 1.05-1.41, adjusted for age and sex). After further adjustment for Charlson score, plasma C-reactive protein (CRP), plasma creatinine and blood hemoglobinlevels, the result remained essentially unaltered (HR per doubling of suPAR: 1.20, 95% CI: 1.01-1.42). In multivariate ROC curve analysis, combining age, sex, Charlson score, CRP, creatinine, and hemoglobin (AUC 0.77, 95% CI 0.75-0.79), the addition of suPAR did not improve the prediction of incident AF (AUC 0.77, 95% CI 0.75-0.79, P=0.89). Plasma suPAR is independently associated with subsequent new-onset AF in a population of recently hospitalized patients, but the addition of suPAR to baseline risk markers appears not to improve the prediction of AF. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ATRIAL fibrillation diagnosis
*UROKINASE
*C-reactive protein
Subjects
Details
- Language :
- English
- ISSN :
- 19416911
- Volume :
- 10
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- JAFIB: Journal of Atrial Fibrillation
- Publication Type :
- Academic Journal
- Accession number :
- 130110761
- Full Text :
- https://doi.org/10.4022/jafib.1801